[PDF] Cellular Defensive Mechanisms of Tea Polyphenols: Structure-Activity Relationship | Semantic Scholar (2024)

This review summarizes the structure-bioactivity relationships, processing parameters that impact polyphenol stability and bioavailability, the research progress in nanocarrier delivery, and the most innovative methodologies for the exhaustive recovery of polyphenols from plant and agri-waste materials.

The review surveys the literature from the late twentieth century until the year 2023 related to the health benefits and therapeutic and toxicological effects associated with these compounds, before and after tannase treatment, related to green tea.

This review focuses on the present understanding of the impact of tea phenolic compounds on the expression of miRNAs, and elucidates the biochemical and molecular mechanisms underlying the transcriptional and post-transcriptional protective actions of tea Phenolic compounds against oxidative stress- and/or inflammation-mediated diseases.

Green tea polyphenols may be considered as adjuvants to treatments for metal-associated diseases related to oxidative stress and DNA damage and demonstrate potential for possible use of GTP to prevent and treat oxidative damage in populations exposed to metals.

Polyphenol intake has been shown to be effective in ameliorating several age-related phenotypes, including oxidative stress, inflammatory processes, impaired proteostasis, and cellular senescence, among other features, which contribute to an increased risk of ageing-associated diseases.

In the analyzed tissues, increased activity of SOD and CAT was recorded as a result of the use of the TA and teas; thus, they can efficiently prevent the prooxidant effect of toxic metals.

An updated overview on the nature and occurrence of polyphenols, quantification methods, bioaccessibility and bioavailability, and impact on human health, namely through interactions with the gut microbiota is provided.

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The evidence for not only the antioxidant, but also pro-oxidant, properties of green tea is discussed in the present review.

When studying the overall cytotoxicity of polyphenols, research strategies need to distinguish the cytotoxic componentderived from the polyphenol per se from that derived from the generated ROS.

Current understanding and information on the role of resveratrol in cellular defense system against oxidative stress are provided.

It is concluded that the pro-oxidant effect of RWp promoted an adaptive stress response in human erythrocytes, which enhances their antioxidant defense, protecting them against oxidative stress.

Most promising are the consistent findings in animal models of skin, lung, colon, liver and pancreatic cancer that tea and tea polyphenol administration inhibit carcinogen-induced increases in the oxidized DNA base, 8-hydroxy-2 -deoxyguanosine.

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